Alternatively Folded Choriogonadotropin Analogs
نویسندگان
چکیده
منابع مشابه
Alternatively folded proteins with unexpected beneficial functions.
HAMLET (human α-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the altern...
متن کاملModification of the choriogonadotropin beta-subunit radioimmunoassay for determination of urinary choriogonadotropin.
The choriogonadotropin beta-subunit radioimminoassay has been used extensively to measure human choriogonadotropin in the sera of pregnant women and individuals with trophoblastic and nontrophoblastic tumors. Unmodified, this method cannot be used to measure choriogonadotropin in urine because of interfering substances. We circumvented the non-parallelism between the standards and serial diluti...
متن کاملChoriogonadotropin-mediated thyrotoxicosis in a man.
A 38-year-old man with a metastatic gonadotropin-secreting tumor of unknown primary origin presented with both clinical and biochemical findings of hyperthyroidism in association with markedly increased concentrations of human choriogonadotropin (hCG) in plasma. After chemotherapy, the concentrations of both hCG and free thyroxin decreased and the patient became euthyroid. We discuss the rare o...
متن کاملPredictableSpecificityfor Differential Measurementof Choriogonadotropin and ItsSubunits
Knowing the epitope specificities of our monoclonal antibodies (MCA) to human choriogonadotropin (hCG), we could design three classes of two-site immunoradiometric assays (IRMA): a combinationof two MCA recognizingtwo separate a-epitopes (a-MCA) provides a system (i.e., an a-IRMA) that measures holo-hCG plus free a-subunitsplus follitropin, lutropin, and thyrotropin, whereas a /3-IRMA, consisti...
متن کاملThe lutropin/choriogonadotropin receptor, a 2002 perspective.
Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m108374200